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The mean heart rate increase in extensive metabolizer EM patients Achat Atomoxetine 18 mg 5. The exposure-efficacy relationship was similar to that observed between dose and efficacy with median exposures at the two highest doses resulting in near maximal changes from baseline [see Clinical Studies].

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Prompt medical attention is required in the event of suspected priapism. In general, the weight and height gain of pediatric patients treated with STRATTERA lags behind that predicted by normative population data for about the first months of treatment.

Growth followed a similar pattern in both extensive and poor metabolizers EMs, PMs. PMs treated for at least two years gained an average of 2. In a fixed-dose controlled trial, Achat Atomoxetine 18 mg, 1.

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Laboratory Tests Routine laboratory tests are not required. Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with STRATTERA and should counsel them in its appropriate use, Achat Atomoxetine 18 mg. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents.

Patients should be given the opportunity to discuss the contents Achat Atomoxetine 18 mg the Medication Guide and to obtain answers to any questions they may have. Suicide Risk Patients, their families, and their caregivers should be encouraged to be alert to the emergence of anxiety, Achat Atomoxetine 18 mg, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia psychomotor restlessnesshypomania, mania, other unusual changes in behavior, depression, and suicidal ideation, especially early during STRATTERA treatment and when the dose is adjusted.

Families and caregivers of patients should be advised to observe for the emergence of such symptoms on a day-to-day basis, since changes may be abrupt, Achat Atomoxetine 18 mg.

Symptoms such as these may be associated with an increased risk for suicidal thinking and behavior and indicate a Achat Atomoxetine 18 mg for very close monitoring and possibly changes in the medication. Aggression Or Hostility Patients should be instructed to call their doctor as soon as possible should they notice an increase in aggression or hostility. Priapism Rare postmarketing cases of priapism, defined as painful and nonpainful penile erection lasting more than 4 hours, have been reported for pediatric and adult patients treated with STRATTERA.

In the event of capsule content coming in contact with the eye, the affected eye should be flushed immediately with water, and medical advice obtained. Hands and any potentially contaminated surfaces should be washed as soon as possible. Drug-Drug Interaction Patients should be instructed to consult a physician if they are taking or plan to take any prescription or over-thecounter medicines, dietary supplements, or herbal remedies.

Interference With Psychomotor Performance Patients should be instructed to use caution when driving a car or operating hazardous machinery until they are reasonably certain that their performance is not affected by atomoxetine. Plasma levels AUC of atomoxetine at this dose in rats are estimated to be 1.

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Mutagenesis Atomoxetine HCl was negative in a battery of genotoxicity studies that included a reverse point mutation assay Ames Testan in vitro mouse lymphoma assay, a chromosomal aberration test in Chinese hamster ovary cells, an unscheduled DNA synthesis test in rat hepatocytes, and an in vivo micronucleus test in mice.

However, there was a slight increase in the percentage of Chinese hamster ovary cells with diplochromosomes, suggesting endoreduplication numerical aberration. At this dose, Achat Atomoxetine 18 mg, in 1 of 3 studies, a decrease in live fetuses and an increase in early resorptions was observed. Slight increases in the incidences of atypical origin of carotid artery and absent subclavian artery were observed.

These findings were observed at doses that caused Achat Atomoxetine 18 mg maternal toxicity.

In 1 of 2 studies, decreases in pup weight and pup survival were observed. No adequate and well-controlled studies have been conducted in pregnant women. Labor And Delivery Parturition in rats was not affected by atomoxetine.

It is not known if atomoxetine is excreted in human milk. The pharmacokinetics of atomoxetine in children and adolescents are similar to those in adults. A study was conducted in young rats to evaluate the effects of atomoxetine on growth and neurobehavioral Achat Atomoxetine 18 mg sexual development, Achat Atomoxetine 18 mg. There were no effects on learning and memory tests. The significance of these findings to humans is unknown.

Gender Gender did not influence atomoxetine disposition.

Ethnic Origin Ethnic origin did not influence atomoxetine disposition except that PMs are more common in Caucasians. Out of patients who entered the acute treatment phase, The primary reason for discontinuation in both the atomoxetine 38 of 76 patients, In a week double-blind, placebo-controlled trial, patients, Achat Atomoxetine 18 mg, agedwho met DSM-IV criteria for ADHD and at least one of the anxiety disorders of separation anxiety disordergeneralized anxiety disorder or social phobia were randomized.

Of the patients who completed the double-blind placebo lead-in, The most commonly reported symptoms accompanying acute and chronic overdoses of STRATTERA were gastrointestinal symptoms, somnolencedizziness, tremorand abnormal behavior. Hyperactivity and agitation have also been reported.

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Signs and symptoms consistent with mild to moderate sympathetic nervous system activation e. Most events were mild to moderate.

Because atomoxetine is highly Achat Atomoxetine 18 mg, dialysis is not likely to be useful in the treatment of overdose. W ith other drugs that affect brain monoamine concentrations, there have been reports of serious, sometimes fatal reactions including hyperthermiarigidity, myoclonusautonomic instability with possible rapid fluctuations of vital signs, and mental status changes that include extreme agitation progressing to delirium and coma when taken in combination with an MAOI.

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